%0 Journal Article
%T Acetylcholine and an acetylcholinesterase inhibitor neostigmine can aggravate tularemia progress in BALB/c mice
%A Miroslav Pohanka
%A Oto Pavlis
%A 
%A Hana Svobodova
%A Jiri Pikula
%J Interdisciplinary Toxicology
%@ 1337-9569
%D 2012
%I 
%R 10.2478/v10102-012-0004-7
%X The present experiment was aimed at assessing the application of neostigmine, an acetylcholinesterase (AChE) pseudo-irreversible inhibitor with poor penetration through the hematoencephalitic barrier, and the neurotransmitter acetylcholine (ACh). The experiment was done to evaluate their ability to modulate an infectious disease: tularemia. Mice infected with Franciselle tularensis and exposed to either ACh or neostigmine had a higher mortality and spleen bacterial burden when compared to infected mice exposed to saline solution only. The activated cholinergic anti-inflammatory pathway suppressed pathways necessary for tularemia resolution. Administration of AChE inhibitors to the individuals suffering from tularemia is contra-indicatory. Drugs based on AChE inhibition should be restricted when tularemia or disease with a similar pathogenesis is suspected.
%K Francisella tularensis
%K intracellular pathogen
%K immunomodulation
%K cholinergic system
%K parasympathicus
%K cholinergic anti-inflammatory pathway
%U http://versita.metapress.com/content/b811126p454qg54u/?p=20d23cb4dd1a4fa59520c2eb904f8cc8&pi=3