%0 Journal Article
%T The toxicokinetics of 2-methylnaphtalene in rats
%A Rados aw  wiercz
%A Wojciech W sowicz
%A Wanda Majcherek
%J International Journal of Occupational Medicine and Environmental Health
%@ 1896-494X
%D 2010
%I Nofer Institute of Occupational Medicine
%R 10.2478/v10001-010-0026-3
%X Background: The aim of the study was to evaluate the toxicokinetics of 2-methylnaphtalene (2-MN) during and after inhalation exposure. Material and Methods: Male Wistar rats were exposed to 2-MN vapours at nominal concentrations of 200 or 400 mg/m3 in the dynamic inhalation chamber for 6 hours or 5 days (6 h/day). Blood samples were collected during and after exposure. Blood concentrations of 2-MN were estimated by gas chromatography using the headspace technique. Results: During a 6-hour exposure to 200 or 400 mg/m3, blood 2-MN concentration increased rapidly within the first or second hour of exposure, respectively, after reaching a plateau. The elimination of 2-MN from blood followed an open two-compartment model. Conclusion: 2-MN was rapidly eliminated from blood of the animals exposed by inhalation to 2-MN. During exposure, lung retention of the chemical was found to decrease. Under conditions of repeated 2-MN exposure, no significant systemic 2-MN accumulation could be observed.
%K 2-Methylnaphtalene
%K Rats
%K Inhalation exposure
%K Blood
%K Toxicokinetics
%U http://versita.metapress.com/content/n5x2062123437352/?p=6e2facbde2354850b66ed2ce268eab65&pi=8