%0 Journal Article
%T Flavonoids in prevention of diseases with respect to modulation of Ca-pump function
%A ubica Hor¨˘kov¨˘
%J Interdisciplinary Toxicology
%@ 1337-9569
%D 2011
%I 
%R 10.2478/v10102-011-0019-5
%X Flavonoids, natural phenolic compounds, are known as agents with strong antioxidant properties. In many diseases associated with oxidative/nitrosative stress and aging they provide multiple biological health benefits. Ca2+-ATPases belong to the main calcium regulating proteins involved in the balance of calcium homeostasis, which is impaired in oxidative/nitrosative stress and related diseases or aging. The mechanisms of Ca2+-ATPases dysfunction are discussed, focusing on cystein oxidation and tyrosine nitration. Flavonoids act not only as antioxidants but are also able to bind directly to Ca2+-ATPases, thus changing their conformation, which results in modulation of enzyme activity. Dysfunction of Ca2+-ATPases is summarized with respect to their posttranslational and conformational changes in diseases related to oxidative/nitrosative stress and aging. Ca2+-ATPases are discussed as a therapeutic tool and the possible role of flavonoids in this process is suggested.
%K flavonoids
%K oxidative/nitrosative stress
%K Ca2+-ATPases in aging and diseases
%U http://versita.metapress.com/content/0722481w88m86356/?p=51cda37345934a3c9183fba1688c45ca&pi=1