%0 Journal Article
%T Ameliorative effect of emblica officinalis aqueous extract on ochratoxin-induced lipid peroxidation in the kidney and liver of mice
%A Devjani Chakraborty
%A Ramtej Verma
%J International Journal of Occupational Medicine and Environmental Health
%@ 1896-494X
%D 2010
%I Nofer Institute of Occupational Medicine
%R 10.2478/v10001-010-0009-4
%X Objectives: The present study was an attempt at investigating whether the aqueous extract of Emblica officinalis may have an ameliorative effect on ochratoxin-induced lipid peroxidation in the kidney and liver of mice. Methods: Adult male albino mice were orally administered 50 ¦Ìg (LD, low dose) and 100 ¦Ìg (HD, high dose) of ochratoxin/0.2 ml of olive oil/animal/day for 45 days. Results: The results revealed a significant (p < 0.05), dose-dependent increase in lipid peroxidation as well as a decreased activity of enzymatic antioxidants (superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glutathione transferase) and non-enzymatic antioxidants (glutathione and total ascorbic acid) in both the organs, as compared to the findings for olive oil-treated control group. Administration of Emblica officinalis aqueous extract (2 mg/animal/day) and ochratoxin for a period of 45 days caused a significant amelioration in the ochratoxin-induced lipid peroxidation in mouse liver and kidney.
%K Kidney
%K Liver
%K Antioxidants
%U http://versita.metapress.com/content/p823211088265173/?p=ef5ae3dc539e42969ed28d5e05b2a72c&pi=7