%0 Journal Article
%T The index of insulin resistance (FIRI) is not associated with plasma homocysteine levels in young, non-obese healthy men and women
%A Anna Czajkowska
%A Ph.D.
%A Gra yna Lutos awska
%A Krzysztof Mazurek
%A Jadwiga Ambroszkiewicz
%A Piotr  mijewski
%J Biomedical Human Kinetics
%@ 2080-2234
%D 2011
%I 
%R 10.2478/v10101-011-0004-7
%X Study aim: To evaluate plasma homocysteine (Hcy), insulin and glucose levels in blood and the insulin resistance index (FIRI) in young, healthy non-obese men and women. Material and methods: A total of 152 young, healthy, non-obese (BMI<30) men (n = 81) and women (n = 71) participated in the study. The following substances were assayed in blood using commercial kits: total plasma homocysteine by fluorescence polarisation immunoassay, plasma glucose - by the oxidase method, and insulin by radioimmunoassay using monoclonal antibodies. From the latter two, the index of insulin resistance (FIRI) was computed. Results: Mean plasma homocysteine concentration in men was significantly (p<0.001) higher than in women (10.3 ¡À 3.0 and 8.4 ¡À 2.4 ¦Ìmol/l, respectively) and that of FIRI was significantly (p<0.001) lower than in women (1.310 ¡À 0.483 and 1.437 ¡À 0.420, respectively). Neither in men nor in women were plasma homocysteine concentrations correlated with FIRI. Conclusions: Although no association between circulating homocysteine and FIRI was found in young, non-obese men and women, the existence of such association in Type 2 diabetes cannot be ruled out.
%K Homocysteine
%K Insulin resistance index
%K Non-obese subjects
%U http://versita.metapress.com/content/krl4781l47701278/?p=60c0f160419e4d168953e9c601166419&pi=0