%0 Journal Article
%T Synthesis and Properties of Methyl 6-Alkylsulfanyl-4-(2-Chlorophenyl)-1,4-Dihydropyridine-3-Carboxylates
%A L. Be ere
%A A. Krauze
%A I.  estakova
%A I. Domra eva
%A Z. And ¨¡ns
%A G. Duburs
%J Latvian Journal of Chemistry
%D 2010
%I 
%R 10.2478/v10161-010-0004-x
%X Methyl 6-alkylsulfanyl-1,4-dihydropyridine-3-carboxylates 7 with optimum lipophilicity have been obtained by treatment of methyl 4-(2-chlorophenyl)-6-thioxo-1,4,5,6-tetrahydropyridine-3-carboxylate 5 with alkyl halides 6. Preparation of target compounds 7 was improved using one-pot five-component synthesis. Methyl 6-ethylsulfanyl-, 6-cyclopropylmethyl-sulfanyl- and 6-isobutylsulfanyl-1,4-dihydropyridine-3-carboxylates 7b, e, f have shown calcium channel blocking activity in in vitro models - SH-SY5Y cell lines (human neuroblastoma).
%K 1
%K 4-dihydropyridine-3-carboxylate
%K 6-thioxo-1
%K 4
%K 5
%K 6-tetra-hydropyridine
%K one-pot five-component synthesis
%K calcium channel blocking activity
%U http://versita.metapress.com/content/q70g3v5367842842/?p=e2cc29d2bc374975a93f28996934d652&pi=3