%0 Journal Article
%T In Vivo Administration of a PKA Type I Inhibitor (Rp-8-Br-cAMPS) Restores T-Cell Responses in Retrovirus-Infected Mice
%A In VivoBtissam Nayjib
%A Mustapha Zeddou
%A Pierre Drion
%A Jacques Boniver
%A Kjetil Tasken
%A Souad Rahmouni
%A Michel Moutschenin vitroex vivo
%J The Open Immunology Journal
%D 2008
%I Bentham Open
%R 10.2174/1874226200801010020]
%X Murine AIDS (MAIDS) is caused by infection with the murine leukemia retrovirus RadLV-Rs and is characterized by T-cell anergy and severe immunodeficiency with increased susceptibilty to several experimental opportunistic infections as observed in HIV infection. T cell anergy is associated with an increase of intracellular cAMP level, triggering a multistep pathway involving activation of PKA type I and resulting in inhibition of proximal TCR signaling. We have previously demonstrated that blocking PKA type I using the selective inhibitor Rp-8-Br-cAMPS, restores T-cell function in vitro in MAIDS as well as in HIV infection. In the present report, we investigated the effect of parenteral administration of Rp-8-Br-cAMPS in mice with MAIDS. We show that the compound is not toxic and partially restores the ex vivo proliferative responses to anti-CD3 mAb, but that it has no effect on the lymphadenopathy and splenomegaly characterizing the MAIDS syndrome.
%U http://www.benthamscience.com/open/toij/articles/V001/20TOIJ.htm