%0 Journal Article
%T SENCAR Mouse Skin Papillomas Induced by 6-Methylbenzo[a]pyrene Carry H-ras Codon 52 (CTALeu ¡ú CCAPro) and Codon 13 (GGCGly ¡ú GTCVal) Mutations
%A rasDhrubajyoti Chakravarti
%A Paula C. Mailander
%A Ercole L. CavalieriEleanor G. RoganIn vitrorasras
%J The Open Dermatology Journal
%D 2007
%I Bentham Open
%R 10.2174/1874372200701010006]
%X Organic smoke contains various methylated polycyclic aromatic hydrocarbon (PAH) carcinogens. Among these, 6-methylbenzo[a]pyrene (6-CH3BP) is a moderate carcinogen. In vitro, it can form both stable and depurinating adducts. Of these, only two depurinating adducts [BP-6-CH2-N7G and 6-CH2BP-(1&3)-N7G] have been detected in mouse skin. We examined seven 6-CH3BP-induced SENCAR mouse skin papillomas for the presence of oncogenic H-ras mutations. Two papillomas contained the codon 52 (CTALeu ¡ú CCAPro) and a third contained the codon 13 (GGCGly ¡ú GTCVal) mutation. These results suggest that the H-ras codon 52 mutation is an oncogenic mutation.
%U http://www.benthamscience.com/open/todj/articles/V001/6TODJ.htm