%0 Journal Article
%T Gentamicin bound to the nanofibre microdispersed oxidized cellulose in the treatment of deep surgical site infections
%A Petr Lochman
%A 
%A Ji ¨ª P¨¢ral
%A 
%A Jarom¨ªr Ko ¨ª
%J Journal of Applied Biomedicine
%@ 1214-0287
%D 2011
%I 
%R 10.2478/v10136-009-0033-5
%X The aim of this experimental in vivo study was to examine the effect of topically-used gentamicin bound to microdispersed oxidized cellulose (MDOC) in nanofibre form in the treatment of deep surgical site infections and to compare it with Garamycin Schwamm . Twelve domestic swine were used in a model of a full-thickness infected dermal wound. The effectiveness of both forms of gentamicin were tested in wound infections caused by Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli. The effectiveness of gentamicin-MDOC and Garamycin Schwamm  were comparable according to microbiological culture findings, with no statistically significant differences. When macroscopically assessed, 100% of the infected wounds treated by gentamicin-MDOC were without signs of infection, compared with only 16.7% when Garamycin Schwamm  was used and this was of statistical significance. Therefore when combined with a nanofibre MDOC carrier, topically-used gentamicin is rendered more effective for the treatment of full-thickness skin infections.
%K gentamicin
%K microdispersed oxidized cellulose
%K surgical site infections
%K Garamycin Schwamm
%U http://versita.metapress.com/content/rg0575408q082617/?p=9d9cff366bae484c82d22488df8149e4&pi=2