%0 Journal Article
%T Crystallization Optimizing of Cefradine
%A Lei DuWenbo Luo
%J The Open Catalysis Journal
%D 2008
%I Bentham Open
%R 10.2174/1876214X01003010019]
%X Cefradine crystallization was studied under different conditions. The optimal conditions for crystallization were: dissolving temperature, 15¡ãC; initial temperature in crystallization, 30¡ãC; cooling temperature in crystallization, 0¡ãC; and adding 1,2-propanediol as adjuvant agent with a volume ratio 0.2 of water solution. The yield of cefradine crystallization is about 92% under these conditions. The purity of cefradine crystals is over 98% under the same conditions. The average size of cefradine crystal is 500 ¦Ìm. The content of cefalexin in crystal is reduced to only 0.36%.
%U http://www.benthamscience.com/open/tocatj/articles/V003/19TOCATJ.htm