%0 Journal Article
%T Prolactin Immunoreactivity in Rheumatoid Factor-Containing Specimens: Is it Prolactin, Macroprolactin or Assay Interference?
%A M.J. Ellis
%A J.H. Livesey and S.G. Soule
%J The Open Clinical Chemistry Journal
%D 2008
%I Bentham Open
%R 10.2174/1874241600801010038]
%X Specimens containing Rheumatoid factor (RF) were examined for possible interference in Prolactin (PRL) measurement. PRL levels following polyethylene glycol (PEG) treatment were significantly lower than in untreated RFpositive samples (p<0.001; n=43) and spurious hyperprolactinemia was indicated in 7 percent. Gel filtration chromatography suggested that the PRL-like immunoreactivity was from assay interference rather than a macroPRL complex and that PEG treatment successfully removed the interference. It is important that laboratories consider explanations other than macroPRL when interpreting PRL results following PEG treatment.
%U http://www.benthamscience.com/open/tocchemj/articles/V001/38TOCCHEMJ.htm