%0 Journal Article
%T Functions of spindle check-point and its relationship to chromosome instability
%A Jianhui Yao
%A Yupeng Zheng
%A Xuebiao Yao
%J Chinese Science Bulletin
%@ 1861-9541
%D 2002
%I 
%R 10.1360/02tb9142
%X It is generally believed that the equal distribution of genetic materials to two daughter cells during mitosis is the key to cell health and development. During the dynamic process, spindle checkpoint plays a very important role in chromosome movements and final sister chromatid separation. The equal and precise segregation of chromosomes contributes to the genomic stability while aberrant separations result in chromosome instability that causes pathogenesis of certain diseases such as DownĄŻs syndrome and cancers. Kinetochore and its regulatory proteins consist of the spindle checkpoint and determine the spatial and temporal orders of chromosome segregation.
%K spindle checkpoint
%K kinetochore
%K chromosome instability
%K cancer
%U http://link.springer.com/article/10.1360/02tb9142