%0 Journal Article
%T Five new polyketides from the basidiomycete Craterellus odoratus
%A Hua Guo
%A Tao Feng
%A Zheng-Hui Li
%A Ji-Kai Liu
%J Natural Products and Bioprospecting
%@ 2192-2209
%D 2012
%I Springer
%R 10.1007/s13659-012-0057-5
%X Five new polyketides, craterellones A¨CE (1¨C5), were isolated from cultures of basidiomycete Craterellus odoratus, together with five known compounds (6¨C10). Structures of 1¨C5 were elucidated on the basis of extensive spectroscopic analysis. All compounds were evaluated for their inhibitory activities against one isozyme of 11¦Â-hydroxysteroid dehydrogenase (11¦Â-HSD1) and cytotoxic activities on five tumor cell lines. Compound 10 exhibited significant cytotoxicity against HL-60, SMMC-7721, A-549, MCF-7, and SW-480, with IC50 values of 0.50, 0.69, 0.64, 1.10, 0.54 ¦ÌM, respectively.
%K Craterellus odoratus
%K craterellones
%K polyketides
%U http://link.springer.com/article/10.1007/s13659-012-0057-5