%0 Journal Article
%T Fatal Lactic Acidosis Associated with Lymphoma, Interferon and Ribavirin¡ì
%A Vidula T. VachharajaniTushar J. Vachharajani
%J The Open Urology & Nephrology Journal
%D 2008
%I Bentham Open
%R 10.2174/1874303X00801010038]
%X Severe lactic acidosis in malignancies is a rare and fatal complication. We report a 51-yr male who presented with fever, fatigue and syncopal episodes and with past medical history of non-Hodgkin¡¯s lymphoma in remission for 3 years, and hepatitis C. He developed severe lactic acidosis and eventually succumbed despite adequate and timely interventions. The clinical presentation resulting from the recurrence of non-Hodgkin¡¯s lymphoma was evident from the initial dramatic response to steroid therapy and confirmed subsequently on histopathology. Mitochondrial toxicity from recent use of peg-interferon and ribavirin possibly contributed to the severity of lactic acidosis.
%U http://www.benthamscience.com/open/tounj/articles/V001/38TOUNJ.htm