%0 Journal Article
%T Genetic Reconstruction of One Hereditary Nonpolyposis Colorectal Cancer History with Multiple Initiations of the Disease
%A Olga A. Vostrukhina
%A Tatyana A. Shtam
%A Alexey V. Gulyaev
%A Kazimir M. Pozharisski and Vladislav A. LanzovMLH1
%J The Open Environmental & Biological Monitoring Journal
%D 2008
%I 
%R 10.2174/1875040000801010043]
%X The scheme of accumulation of genetic alterations in a long-term case of hereditary nonpolyposis colorectal cancer (HNPCC) was reconstructed by the retrospective analysis of postoperative tissue materials. This unique case resulted from a primary lesion in MLH1 gene and revealed two genetic pathways of carcinogenesis in tumors separated by lifetime and localization.
%U http://www.benthamscience.com/open/toebmj/articles/V001/43TOEBMJ.htm