%0 Journal Article %T Genetic Reconstruction of One Hereditary Nonpolyposis Colorectal Cancer History with Multiple Initiations of the Disease %A Olga A. Vostrukhina %A Tatyana A. Shtam %A Alexey V. Gulyaev %A Kazimir M. Pozharisski and Vladislav A. LanzovMLH1 %J The Open Environmental & Biological Monitoring Journal %D 2008 %I %R 10.2174/1875040000801010043] %X The scheme of accumulation of genetic alterations in a long-term case of hereditary nonpolyposis colorectal cancer (HNPCC) was reconstructed by the retrospective analysis of postoperative tissue materials. This unique case resulted from a primary lesion in MLH1 gene and revealed two genetic pathways of carcinogenesis in tumors separated by lifetime and localization. %U http://www.benthamscience.com/open/toebmj/articles/V001/43TOEBMJ.htm