%0 Journal Article
%T Different Evolution of Inhibitory and Activating Killer Immunoglobulin Receptors (KIR) in Worldwide Human Populations
%A Derek Middleton
%A Ashley Meenagh
%A Juan Ignacio Serrano-Vela
%A Juan MoscosoAntonio Arnaiz-Villen
%J The Open Immunology Journal
%D 2008
%I Bentham Open
%R 10.2174/1874226200801010042]
%X HLA class I molecules are ligands for natural killer cellsĄŻ inhibitory (KIR DL) and activating (KIR DS) receptors. KIR DL receptors have a greater avidity for HLA class I molecules than KIR DS receptors. Thus, there is a possibility that HLA molecules drive KIR receptor selection. We have used the percentage of individuals bearing the genes KIR 3DS1, 2DS1, 2DS2, 2DS3, 2DS4, 2DS5, 2DL1, 2DL2, 2DL3, 2DL5 and 3DL1 in relatively well defined populations to test whether there is a different way of relating worldwide populations between KIR DS and KIR DL molecules. We have used ARLEQUIN, DISPAN and VISTA computer programs to construct dendrograms and correspondence analyses showing the genetic relationships among different human world populations. Analyses based on KIR DS or KIR haplotype B genes show that populations are related according to geography, like a good anthropological marker (i.e.: HLA or Y chromosome systems). The results based on KIR DL or KIR haplotype A genes do not show such a correlation. Results are discussed taking into account the linkage of both HLA and KIR systems to microbial diseases and the possible evolutionary shaping of both HLA and KIR receptors repertoire by pathogens.
%U http://www.benthamscience.com/open/toij/articles/V001/42TOIJ.htm