%0 Journal Article
%T High-Lycopene Tomato Intake Increases Serum Carotenoid Levels but not Biomarkers of Oxidative Stress and Inflammation in Healthy Adults
%A C.A. Thomson
%A N.R. Stendell-Hollis
%A J.L. West
%A E.C. Cussler
%A L.M. McCune
%A M. Kroggel
%A H.J. KimC. KubotatranscisPcisP
%J The Open Bioactive Compounds Journal
%D 2009
%I 
%R 10.2174/1874847300801010007]
%X Fresh tomatoes higher in lycopene content than standard varieties have recently been designed. We hypothesized that consumption of fresh, high lycopene tomatoes (HEC) for 3-weeks, as compared to standard fresh tomatoes, (LEC) would result in significant increases in serum lycopene and reductions in oxidative stress and inflammation. Forty healthy adult men (37.5%) and women (62.5%) age 55.3¡À4.7 years (BMI = 25.1¡À3.3 kg/m2) completed this randomized, crossover, controlled tomato intervention. Serum lycopene, oxidative stress (8-OHdG, 8-iso-PGF2¦Á) and inflammation (hsCRP) were assessed. Significant increases were seen in trans- and cis-lycopene (pre- and post-intervention, P < 0.0001), with cis-lycopene increasing significantly more during HEC consumption as compared to LEC (P=0.03). No significant changes in 8-OHdG, 8-iso-PGF2¦Á or hsCRP were demonstrated. Consumption of HEC tomatoes resulted in significant elevations in serum lycopene but not significant reductions in oxidative stress or inflammation in this healthy adult population.
%U http://www.benthamscience.com/open/tobcj/articles/V001/7TOBCJ.htm