%0 Journal Article
%T Role of Tip60 tumor suppressor in DNA repair pathway
%A ZhiJian Liu
%A YingLi Sun
%J Chinese Science Bulletin
%@ 1861-9541
%D 2011
%I 
%R 10.1007/s11434-011-4433-z
%X To prevent the damage caused by DNA strand breaks, eukaryotic cells have evolved a series of highly conserved DNA repair mechanisms. The ubiquitously expressed acetyltransferase, Tip60, plays a central role in ATM (ataxia-telangiectasia mutated) activation which is involved in DNA repair. Recent work uncovered a new mechanism of ATM activation mediated by Tip60 and demonstrated that histone methylation, specifically, trimethylation of histone H3, is a key factor in the process. Here, we review the current understanding of how Tip60 is activated and how it activates ATM in response to DNA damage.
%K Tip60
%K ATM
%K MRN
%K histone methylation
%K DNA damage
%K DNA repair
%U http://link.springer.com/article/10.1007/s11434-011-4433-z