%0 Journal Article
%T Progress in studies of angiostatin and its anti-tumor effects
%A Hong Yang
%A Yin Wu
%A Yuxin Li
%A Tonghui Ma
%A Baiqu Huang
%J Chinese Science Bulletin
%@ 1861-9541
%D 2001
%I 
%R 10.1007/BF03187254
%X Angiostatin is a 38 ku circulating angiogenesis inhibitor purified from the serum and urine of mice bearing a murine Lewis lung carcinoma. It is regarded as an internal fragment of plasminogen containing the first 4 Kringle structures.In vitro, angiostatin specifically inhibits endothelial cell proliferation.In vivo, it inhibits angiogenesis and suppresses the growth of such primary tumors as Lewis lung carcinoma and hemangioendotheliolma in mice.
%K angiostatin
%K angiogenesis
%K endothelial cell
%K anti-tumor
%U http://link.springer.com/article/10.1007/BF03187254