%0 Journal Article
%T Rearrangement mechanism of the sodium adducts of Fmoc protected amino acids
%A Jintang Du
%A Yanmei Li
%A Zhentai Zhu
%A Yi Chen
%A Yufen Zhao
%J Chinese Science Bulletin
%@ 1861-9541
%D 2003
%I 
%R 10.1360/03wb0093
%X The cationized 9-fluorenylmethoxycarbonyl (Fmoc) protected amino acids were analyzed by the electrospray ionization tandem mass spectrometry (ESI-MS/MS). A rearrangement reaction leading to the C-terminal hydroxyl group transfer was observed. The sodium adducts of Fmoc-OH was formed. A possible rearrangement mechanism was proposed. The rearrangement reaction depended on the Fmoc group, metal ions and metal ion radius. It was shown that the Fmoc group has a strong affinity to the hydroxyl group in the gas phase.
%K Fmoc protected amino acids
%K rearrangement reaction
%K ESI-MS
%K protein sequencing
%K peptide
%U http://link.springer.com/article/10.1360/03wb0093