%0 Journal Article
%T One-step synthesis of Lycopodium alkaloid (-)-huperzine W via Suzuki-Miyaura coupling
%A Tao Xu
%A Shi-Zhi Jiang
%A Huai-Rong Luo
%A Yu-Rong Yang
%J Natural Products and Bioprospecting
%@ 2192-2209
%D 2012
%I Springer
%R 10.1007/s13659-012-0084-2
%X The first total synthesis of ( )-huperzine W (1) has been achieved. Key element of the synthesis is a highly convergent assemblage for the two rings system of target molecule utilizing an efficient Suzuki-Miyaura coupling reaction between chiral iodide 2 and 2-allylpyrrolidinone 4. Evaluation of the AchE inhibition of synthetic huperzine W was also carried out.
%K total synthesis
%K huperzine W
%K lycopodium alkaloids
%U http://link.springer.com/article/10.1007/s13659-012-0084-2