%0 Journal Article %T One-step synthesis of Lycopodium alkaloid (-)-huperzine W via Suzuki-Miyaura coupling %A Tao Xu %A Shi-Zhi Jiang %A Huai-Rong Luo %A Yu-Rong Yang %J Natural Products and Bioprospecting %@ 2192-2209 %D 2012 %I Springer %R 10.1007/s13659-012-0084-2 %X The first total synthesis of ( )-huperzine W (1) has been achieved. Key element of the synthesis is a highly convergent assemblage for the two rings system of target molecule utilizing an efficient Suzuki-Miyaura coupling reaction between chiral iodide 2 and 2-allylpyrrolidinone 4. Evaluation of the AchE inhibition of synthetic huperzine W was also carried out. %K total synthesis %K huperzine W %K lycopodium alkaloids %U http://link.springer.com/article/10.1007/s13659-012-0084-2