%0 Journal Article
%T ¦Â-carboline alkaloids from Trigonostemon filipes and Trigonostemon lii
%A Shi-Fei Li
%A Yuan-Yuan Cheng
%A Yu Zhang
%A Shun-Lin Li
%A Hong-Ping He
%A Xiao-Jiang Hao
%J Natural Products and Bioprospecting
%@ 2192-2209
%D 2012
%I Springer
%R 10.1007/s13659-012-0028-x
%X Six ¦Â-carboline alkaloids including three new ones, trifilines A-C (1¨C3) were isolated from Trigonostemon filipes, along with a new ¦Â-carboline alkaloid, trigonoine C (7) isolated from Trigonostemon lii. Their structures were elucidated by extensive spectroscopic techniques. Trifilines A (1) and B (2) showed weak anti-HIV-1 activity with EC50 values of 54.61 ¦Ìg/mL and 9.75 ¦Ìg/mL, along with TI (Therapeutic index) values of 1.52 and 1.42, respectively. This is the first time to report the chemical constituents of Trigonostemon filipes.
%K Trigonostemon filipes
%K Trigonostemon lii
%K ¦Â-carboline alkaloids
%K trifilines A-C
%K trigonoine C
%U http://link.springer.com/article/10.1007/s13659-012-0028-x