%0 Journal Article
%T Study of ionizable drugs transfer across the water/ 1,2-dichloroethane interface with phase volume ratio equal to unity using a three-electrode system
%A Meiqin Zhang
%A Peng Sun
%A Yong Chen
%A Fei Li
%A Zhao Gao
%A Yuanhua Shao
%J Chinese Science Bulletin
%@ 1861-9541
%D 2003
%I 
%R 10.1007/BF03183944
%X The electrochemical behavior of ionizable drugs (Amitriptyline, Diphenhydramine and Trihexyphenedyl) at the water/1,2-dichloroethane interface with the phase volume ratio (r = V o/Vw) equal to 1 are investigated by cyclic voltammetry. The system is composed of an aqueous droplet supported at an Ag/AgCl disk electrode and it was covered with an organic solution. In this manner, a conventional three-electrode potentiostat can be used to study the ionizable drugs transfer process at a liquid/liquid interface. Physicochemical parameters such as the formal transfer potential, the Gibbs energy of transfer and the standard partition coefficients of the ionized forms of these drugs can be evaluated from cyclic voltammograms obtained. The obtained results have been summarized in ionic partition diagrams, which are a useful tool for predicting and interpreting the transfer mechanisms of ionizable drugs at the liquid/liquid interfaces and biological membranes.
%K water/1
%K 2-dichloroethane interface
%K ionizable drug transfer
%K three-electrode system
%K phase volume ratio
%K ionic partition diagram
%U http://link.springer.com/article/10.1007/BF03183944