%0 Journal Article
%T Use of a physiologically-based pharmacokinetic model to simulate artemether dose adjustment for overcoming the drug-drug interaction with efavirenz
%A Marco Siccardi
%A Adeniyi Olagunju
%A Kay Seden
%A Farid Ebrahimjee
%A Steve Rannard
%A David Back and Andrew Owen
%J In Silico Pharmacology
%D 2013
%I Springer
%R 10.1186/2193-9616-1-4
%X The model presented here provides a rational platform to inform the design for a clinical drug interaction study that may save time and resource while the optimal dose is determined empirically. Wider application of IVIVE could help researchers gain a better understanding of the molecular mechanisms underpinning variability in drug disposition.
%K Artemether
%K IVIVE
%K Efavirenz
%K Drug interaction
%K Pharmacokinetics
%K Simulation
%U http://www.in-silico-pharmacology.com/content/1/1/4/abstract