%0 Journal Article
%T Incretin secretion stimulated by ursodeoxycholic acid in healthy subjects
%A Masanori Murakami
%A Naoko Une
%A Maiko Nishizawa
%A Sayaka Suzuki
%A Hideki Ito and Toshiyuki Horiuchi
%J SpringerPlus
%D 2013
%I Springer
%R 10.1186/2193-1801-2-20
%X Bile acids play an important role in post-prandial glucose metabolism by stimulating release of glucagon-like peptide-1 (GLP-1) via the G-protein-coupled receptor TGR5, which is expressed in intestinal L cells. Thus, bile acid sequestrants are expected to stimulate secretion of endogenous GLP-1 through TGR5. We investigated incretin and insulin secretion after a meal with and without ursodeoxycholic acid (UDCA), a widely used therapeutic agent in liver diseases, in 7 non-diabetic Japanese subjects. We found that UDCA intake resulted in higher GLP-1 secretion (area under the curve [AUC] of 0¨C60 min after meal without UDCA, 450 ¡À 162 mmol¡¤min/l; with UDCA, 649 ¡À 232 mmol¡¤min/l, P = 0.046) and lower blood glucose (AUC of 0¨C60 min without UDCA, 7191 ¡À 250 mg¡¤min/dl; with UDCA, 6716 ¡À 189 mg¡¤min/dl, P = 0.001) , although we did not find statistically significant insulin increase by UDCA intake (AUC of 0¨C60 min without UDCA, 1551 ¡À 418 ¦ÌU¡¤min/ml; with UDCA, 1941 ¡À 246 ¦ÌU¡¤min/ml, P = 0.065). These results suggest that UDCA increases bile-induced GLP-1 secretion. Ours is the first report showing increased GLP-1 secretion and decreased blood glucose in response to UDCA.
%K Bile acid
%K Ursodeoxycholic acid
%K Glucagon-like peptide-1
%U http://www.springerplus.com/content/2/1/20/abstract