%0 Journal Article
%T A Novel Strategy to Screen Bacillus Calmette-Gu¨¦rin Protein Antigen Recognized by ¦Ã¦Ä TCR
%A XueYan Xi
%A XiaoYan Zhang
%A Bei Wang
%A Ji Wang
%A He Huang
%A LianXian Cui
%A XiQin Han
%A Liang Li
%A Wei He
%A ZhenDong Zhao
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0018809
%X Phosphoantigen was originally identified as the main ¦Ã¦Ä TCR-recognized antigen that could activate ¦Ã¦Ä T cells to promote immune protection against mycobacterial infection. However, new evidence shows that the ¦Ã¦Ä T cells activated by phosphoantigen can only provide partial immune protection against mycobacterial infection. In contrast, whole lysates of Mycobacterium could activate immune protection more potently, implying that other ¦Ã¦Ä TCR-recognized antigens that elicit protective immune responses. To date, only a few distinct mycobacterial antigens recognized by the ¦Ã¦Ä TCR have been characterized.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0018809