%0 Journal Article %T Effects of dragon¡¯s blood resin and its component loureirin B on tetrodotoxinsensitive voltage-gated sodium currents in rat dorsal root ganglion neurons %A Liu Xiangming %A Chen Su %A Yin Shijin %A Mei Zhinan %J Science China Life Sciences %@ 1869-1889 %D 2004 %I %R 10.1360/03yc0146 %X Using whole-cell patch clamp technique on the membrane of freshly isolated dorsal root ganglion (DRG) neurons, the effects of dragon¡¯s blood resin and its important component loureirin B on tetrodotoxin-sensitive (TTX-S) voltage-gated sodium currents were observed. The results show that both blood resin and loureirin B could suppress TTX-S voltage-gated sodium currents in a dose-dependent way. The peak current amplitudes and the steady-state activation and inactivation curves are also made to shift by 0.05% blood resin and 0.2 mmol/L loureirin B. These results demonstrate that the effects of blood resin on TTX-S sodium current may contribute to loureirin B in blood resin. Perhaps the analgesic effect of blood resin is caused partly by loureirin B directly interfering with the nociceptive transmission of primary sensory neurons. %K blood resin %K loureirin B %K dorsal root ganglion neurons %K tetrodotoxin-sensitive sodium channel %U http://link.springer.com/article/10.1360/03yc0146