%0 Journal Article
%T Androgen receptor coregulator ARA267-¦Á interacts with death receptor-6 revealed by the yeast two-hybrid
%A Tiejun Mai
%A Xin Wang
%A Zhiwen Zhang
%A Dianqi Xin
%A Yanqun Na
%A Yinglu Guo
%J Science China Life Sciences
%@ 1869-1889
%D 2004
%I 
%R 10.1007/BF03187102
%X ARA267-¦Á is a newly identified androgen receptor coactivator. In order to further elucidate its precise role in cells, using the ARA267-¦Á fragment containing four PHD and one SET conserved domains as bait we revealed an ARA267-¦Á-PHD-SET-interacting protein, death receptor-6 (DR6), in the yeast two-hybrid screening. DR6 is the member of TNF receptor family and has a death domain in its intracellular cytoplasmic portion (DR6cp) to mediate the cell apoptosis. The interaction between ARA267-¦Á-PHD-SET and DR6cp was confirmedin vitro andin vivo. Our finding implied that androgen signaling pathway might cross talk with apoptosis signaling pathway through the interaction between ARA267-¦Á and DR6.
%K ARA267-¦Á
%K androgen receptor
%K androgen receptor coregulator
%K death receptor-6
%K yeast two-hybrid system
%U http://link.springer.com/article/10.1007/BF03187102