%0 Journal Article
%T Characterization of 9-Nitrocamptothecin Liposomes: Anticancer Properties and Mechanisms on Hepatocellular Carcinoma In Vitro and In Vivo
%A Shunzhen Zheng
%A Shuang Chang
%A Jinli Lu
%A Zhihui Chen
%A Li Xie
%A Yu Nie
%A Bin He
%A Shengquan Zou
%A Zhongwei Gu
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0021064
%X Hepatocellular carcinoma (HCC) is the third most common cause of cancer related mortality worldwide. 9-Nitrocamptothecin (9NC) is a potent topoisomerase-I inhibitor with strong anticancer effect. To increase the solubility and stability, we synthesized a novel 9NC loaded liposomes (9NC-LP) via incorporating 9NC into liposomes. In the present study, we determined the effects of 9NC and 9NC-LP on in vitro and in vivo, and the underlying mechanisms.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0021064