%0 Journal Article %T Bleeding Risk during Treatment of Acute Thrombotic Events with Subcutaneous LMWH Compared to Intravenous Unfractionated Heparin; A Systematic Review %A Giorgio Costantino %A Elisa Ceriani %A Anna Maria Rusconi %A Gian Marco Podda %A Nicola Montano %A Piergiorgio Duca %A Marco Cattaneo %A Giovanni Casazza %J PLOS ONE %D 2012 %I Public Library of Science (PLoS) %R 10.1371/journal.pone.0044553 %X Low Molecular Weight Heparins (LMWH) are at least as effective antithrombotic drugs as Unfractionated Heparin (UFH). However, it is still unclear whether the safety profiles of LMWH and UFH differ. We performed a systematic review to compare the bleeding risk of fixed dose subcutaneous LMWH and adjusted dose UFH for treatment of venous thromboembolism (VTE) or acute coronary syndromes (ACS). Major bleeding was the primary end point. %U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0044553