%0 Journal Article
%T Mice with a Targeted Deletion of the Type 2 Deiodinase Are Insulin Resistant and Susceptible to Diet Induced Obesity
%A Alessandro Marsili
%A Cristina Aguayo-Mazzucato
%A Ting Chen
%A Aditi Kumar
%A Mirra Chung
%A Elaine P. Lunsford
%A John W. Harney
%A Thuy Van-Tran
%A Elena Gianetti
%A Waile Ramadan
%A Cyril Chou
%A Susan Bonner-Weir
%A Philip Reed Larsen
%A Jorge Enrique Silva
%A Ann Marie Zavacki
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0020832
%X The type 2 iodothyronine deiodinase (D2) converts the pro-hormone thyroxine into T3 within target tissues. D2 is essential for a full thermogenic response of brown adipose tissue (BAT), and mice with a disrupted Dio2 gene (D2KO) have an impaired response to cold. BAT is also activated by overfeeding.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0020832