%0 Journal Article
%T LRRK2 A419V Is Not Associated with Parkinson's Disease in Different Chinese Populations
%A Yih Ru Wu
%A Louis C. Tan
%A Xiaoli Fu
%A Chiung Mei Chen
%A Wing Lok Au
%A Ling Chen
%A Yi Chun Chen
%A Kumar M. Prakash
%A Yifan Zheng
%A Guey-Jen Lee-Chen
%A Yi Zhao
%A Jin-Sheng Zeng
%A Eng King Tan
%A Zhong Pei
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0036123
%X It has been suggested that a common LRRK2 polymorphic variant (A419V (rs34594498 C >T)) may be a risk factor among Asians (especially in Taiwan). In this study, we examined this variant in a larger and independent Taiwan cohort. We found the frequency of the variant (A419V) to be very rare in our Taiwan PD and controls (?0.6%). Further studies were conducted in two other Chinese populations (Singapore and China), comprising of a total of 3004 subjects including 1517 PD patients and 1487 control subjects. However, our multi-center Chinese study revealed that the frequency of the variant was rare (?0.4%) and was not associated with risk of PD, suggesting that the variant is not a major risk factor for PD among Chinese, at least in our study population.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0036123