%0 Journal Article
%T Targeting of ¦Â-Arrestin2 to the Centrosome and Primary Cilium: Role in Cell Proliferation Control
%A Anahi Molla-Herman
%A Cedric Boularan
%A Rania Ghossoub
%A Mark G. H. Scott
%A Anne Burtey
%A Marion Zarka
%A Sophie Saunier
%A Jean-Paul Concordet
%A Stefano Marullo
%A Alexandre Benmerah
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0003728
%X The primary cilium is a sensory organelle generated from the centrosome in quiescent cells and found at the surface of most cell types, from where it controls important physiological processes. Specific sets of membrane proteins involved in sensing the extracellular milieu are concentrated within cilia, including G protein coupled receptors (GPCRs). Most GPCRs are regulated by ¦Â-arrestins, ¦Âarr1 and ¦Âarr2, which control both their signalling and endocytosis, suggesting that ¦Âarrs may also function at primary cilium.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0003728