%0 Journal Article
%T CNTNAP2 and Language Processing in Healthy Individuals as Measured with ERPs
%A Miriam Kos
%A Danielle van den Brink
%A Tineke M. Snijders
%A Mark Rijpkema
%A Barbara Franke
%A Guillen Fernandez
%A Peter Hagoort
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0046995
%X The genetic FOXP2-CNTNAP2 pathway has been shown to be involved in the language capacity. We investigated whether a common variant of CNTNAP2 (rs7794745) is relevant for syntactic and semantic processing in the general population by using a visual sentence processing paradigm while recording ERPs in 49 healthy adults. While both AA homozygotes and T-carriers showed a standard N400 effect to semantic anomalies, the response to subject-verb agreement violations differed across genotype groups. T-carriers displayed an anterior negativity preceding the P600 effect, whereas for the AA group only a P600 effect was observed. These results provide another piece of evidence that the neuronal architecture of the human faculty of language is shaped differently by effects that are genetically determined.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0046995