%0 Journal Article
%T Interferon-¦Â Signaling Contributes to Ras Transformation
%A Yu-Chen Tsai
%A Sidney Pestka
%A Lu-Hai Wang
%A Loren W. Runnels
%A Shan Wan
%A Yi Lisa Lyu
%A Leroy F. Liu
%J PLOS ONE
%D 2011
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0024291
%X Increasing evidence has pointed to activated type I interferon signaling in tumors. However, the molecular basis for such activation and its role in tumorigenesis remain unclear. In the current studies, we report that activation of type I interferon (IFN) signaling in tumor cells is primarily due to elevated secretion of the type I interferon, IFN-¦Â. Studies in oncogene-transformed cells suggest that oncogenes such as Ras and Src can activate IFN-¦Â signaling. Significantly, elevated IFN-¦Â signaling in Ras-transformed mammary epithelial MCF-10A cells was shown to contribute to Ras transformation as evidenced by morphological changes, anchorage-independent growth, and migratory properties. Our results demonstrate for the first time that the type I IFN, IFN-¦Â, contributes to Ras transformation and support the notion that oncogene-induced cytokines play important roles in oncogene transformation.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0024291