%0 Journal Article
%T Clinical factors influencing the resting and stimulated salivary flow
%A Shigeo Yamachika
%A Ken Yamamoto
%A Yoshiaki Nomura
%A Hiroyuki Yamada
%A Ichiro Saito
%A Yoichi Nakagawa
%J Open Journal of Stomatology
%P 103-109
%@ 2160-8717
%D 2012
%I Scientific Research Publishing
%R 10.4236/ojst.2012.22019
%X Objective: The objective of this study was to examine the clinical and immunological factors influ encing sialometry in xerostomia patients. Method: The association between sialometry and other clinical examinations were investigated in a cross-sectional study. A total of 179 dry mouth patients showing hyposalivation who underwent a clinical examination were enrolled in this study. Multiple regression analyses were employed to examine the relative con-tributions of clinical and immunological factors including age, gender, parotid sialography, labial Salivary gland biopsy, anti-Ro/SS-A antibodies, and anti-La/SS-B antibodies to the resting (RSF) or stimulated saliva flow rate (SSF). Results: An increase of the stage of sialography, the grade of a labial biopsy, and the presence of anti-La/SS-B antibody had a significant correlation with a decrease of sialometry. Results of the multiple regression analysis showed that age (standardized coefficient = -0.244), grade of lip biopsy (-0.189), and anti-SS-B antibody (-0.171), were significantly associated with the RSF. The stage of sialography (?0.423) and age (-0.169) were significantly related to the sialometry in the SSF according to a multiple regression analysis. Conclusion: The results of this study suggest that the measurement of RSF reflects the immunological factors and SSF reflects the damage to the parotid gland.
%K Xerostomia
%K Sialometry
%K Sialography
%K Labial Minor Salivary Gland Biopsy
%K Sj&#246
%K gren¡¯s Syndrome
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=19625