%0 Journal Article
%T CYTOTOXIC LABDANE DITERPENOIDS ISOLATED FROM THE HEXANE FRACTION OF THE Croton stipuliformis STEM BARK
%A FRANCO
%A Martha S
%A CORDERO
%A Claudia P
%A MORANTES
%A Sandra J
%A ARISTIZABAL
%A Fabio
%A OSORIO
%A Coralia
%J Vitae
%D 2011
%I Universidad de Antioquia
%X the composition of the cytotoxic hexane fraction of the croton stipuliformis bark was studied by means of a gas chromatography coupled to a mass spectrometry; sesquiterpenes and sterols were characterized as the main constituents. along with these compounds, three labdane and seco-labdane diterpenoids, 8(17),12e,14-labdatrien-18-oic acid [3], 12e-3,4-seco-labda-4(18),8(17),12,14-tetraen-3-oic acid [2], and its methyl ester [1] were isolated from this fraction through preparative hplc, and their structures were elucidated by hr-fabms, 1d and 2d nmr analyses. additionally, the cytotoxic activity of these three compounds against human tumor cell lines hep-2, ht-29, mkn-45, mcf-7, and hela was assessed. the three compounds showed a non-specific and moderate cytotoxicity against the abovementioned cell lines.
%K croton stipuliformis
%K euphorbiaceae
%K labdane
%K mtt assay
%K cytotoxicity.
%U http://www.scielo.org.co/scielo.php?script=sci_abstract&pid=S0121-40042011000200008&lng=en&nrm=iso&tlng=en