%0 Journal Article
%T Citotoxicidad y actividad anticancer¨ªgena de dos flavonoides aislados y purificados de Brownea ariza Brenth
%A GIL R
%A Juan F
%A Milton
%A G¨®MEZ B
%A TREJOS S
%A Juanita
%J Vitae
%D 2009
%I Universidad de Antioquia
%X the growing resistance to anticancer agents has turned medical science and pharmacology towards finding new compounds with these characteristics; in this area the natural products have great relevance, since many of these have anticancer activity. flavonoids as secondary metabolites have reported anti-tumor activity and can become important source for cancer treatment; why search isolate flavonoids brownea ariza brenth to evaluate their anticancer activity. the phytochemical analysis of leaves of brownea ariza brenth. (caesalpiniaceae) let isolate a flavonol identified as (1), and a glycoside flavonol described as quercitrin (2). the structures are determined by spectroscopic techniques: uv-vis with shift reagents; 1d and 2d nmr (1h, 13c, cosy, dept, hmbc; hmqc), and mass spectrometry. it evaluates the cytotoxic activity in vero cell (atcc: ccl-81) and anticancer activity in myeloma murino sp2/0-ag14 (atcc: crl-1581), doing count the number of viable cells by graduation with tripan blue, obtaining a concentration cytotoxic average (1) of 300 ¦̀g/ml and not determined to (2) in concentrations of work; anticancer activity for (1) has a median effective concentration of 150 ¦̀g /ml and not given to (2) in concentrations of work.
%K isolation
%K purification
%K flavonoids
%K cytotoxicity
%K anti-cancer agents
%K brownea ariza.
%U http://www.scielo.org.co/scielo.php?script=sci_abstract&pid=S0121-40042009000100011&lng=en&nrm=iso&tlng=en