%0 Journal Article
%T The Epoxygenases CYP2J2 Activates the Nuclear Receptor PPAR¦Á In Vitro and In Vivo
%A Jessica A. Wray
%A Mary C. Sugden
%A Darryl C. Zeldin
%A Gemma K. Greenwood
%A Salma Samsuddin
%A Laura Miller-Degraff
%A J. Alyce Bradbury
%A Mark J. Holness
%A Timothy D. Warner
%A David Bishop-Bailey
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0007421
%X Peroxisome proliferator-activated receptors (PPARs) are a family of three (PPAR¦Á, -¦Â/¦Ä, and -¦Ã) nuclear receptors. In particular, PPAR¦Á is involved in regulation of fatty acid metabolism, cell growth and inflammation. PPAR¦Á mediates the cardiac fasting response, increasing fatty acid metabolism, decreasing glucose utilisation, and is the target for the fibrate lipid-lowering class of drugs. However, little is known regarding the endogenous generation of PPAR ligands. CYP2J2 is a lipid metabolising cytochrome P450, which produces anti-inflammatory mediators, and is considered the major epoxygenase in the human heart.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0007421