%0 Journal Article
%T p53 Amino-Terminus Region (1¨C125) Stabilizes and Restores Heat Denatured p53 Wild Phenotype
%A Anuj Kumar Sharma
%A Amjad Ali
%A Rajan Gogna
%A Amir Kumar Singh
%A Uttam Pati
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0007159
%X The intrinsically disordered N-ter domain (NTD) of p53 encompasses approximately hundred amino acids that contain a transactivation domain (1¨C73) and a proline-rich domain (64¨C92) and is responsible for transactivation function and apoptosis. It also possesses an auto-inhibitory function as its removal results in remarkable reduction in dissociation of p53 from DNA.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0007159