%0 Journal Article
%T Adjunctive micronutrient supplementation for pulmonary tuberculosis
%A Armijos
%A Rodrigo X
%A Weigel
%A M Margaret
%A Chacon
%A Roc¨ªo
%A Flores
%A Luis
%A Campos
%A Armando
%J Salud P¨²blica de M¨¦xico
%D 2010
%I Instituto Nacional de Salud P¨²blica
%R 10.1590/S0036-36342010000300001
%X objective: to assess the effect of micronutrient supplementation on tuberculosis (tb) patient outcomes. material and methods: the randomized, double-blinded, placebo-controlled study was conducted in pulmonary tb patients undergoing directly observed treatment short course/ tratamiento acortado estrictamente supervisado (taes/ dots) at imss in ciudad juarez, chihuahua, mexico, who were recruited during august 2005-july 2006. consecutive patients received zinc and vitamin a supplements or matched placebo for four months. dietary intake, blood zinc and vitamin a, immune response (ifn-¦Ã,tnf-¦Á, and il-10 mrna), and sputum smear conversion were measured. results: the proportion of micronutrient compared to placebo group subjects with a negative sputum smear by month 3 was significantly increased (p= 0.03). this occurred subsequent to increased tnf-¦Á and ifn-¦Ã and decreased il-'0 observed at month 2. micronutrient supplementation appeared to accelerate the beneficial therapeutic effect of chemotherapy. conclusions: the earlier elimination of bacilli from sputum was associated with improved zinc status and th' immune response. the therapeutic effect of vitamin a was less evident.
%K pulmonary
%K tuberculosis
%K zinc
%K vitamin a
%K cytokines
%K mexico.
%U http://www.scielosp.org/scielo.php?script=sci_abstract&pid=S0036-36342010000300001&lng=en&nrm=iso&tlng=en