%0 Journal Article
%T Acidosis l¨¢ctica severa asociada a infusi¨®n de propofol: Caso cl¨ªnico
%A Romero P
%A Carlos
%A Morales R
%A M¨®nica
%A Donaire R
%A Luisa
%A Llanos V
%A Osvaldo
%A Cornejo R
%A Rodrigo
%A G¨¢lvez A
%A Ricardo
%A Castro O
%A Jos¨¦
%J Revista m¨¦dica de Chile
%D 2008
%I Sociedad M¨¦dica de Santiago
%R 10.4067/S0034-98872008000100011
%X propofol infusion syndrome (pris) is a rare but potentially lethal complications. this disorder is triggered under unknown circumstances by a propofol infusion of more than 5 mg/kg/h for more than 48 h. pris is characterized by a multiorgan failure and rhabdomyolysis and is induced by a disturbance in mitochondrial long chain fatty acid oxidation. we report a 43 year-old woman who underwent brain surgery due to a vascular malformation. in the immediate postoperative period, she had an unexplained and severe lactic acidosis. during anaesthesia, she received a propofol infusion of 7 mg/kg/h that continued in the uci at a rate of 3.5 mg/kg/h, for 8 hours more. the suspicion of pris motivated immediate discontinuation of propofol with rapid correction of lactic acidosis and full recovery of the patient (rev m¨¦d chile 2008; 136: 88-92)
%K acidosis
%K lactic
%K propofol
%K rhabdomyolysis.
%U http://www.scielo.cl/scielo.php?script=sci_abstract&pid=S0034-98872008000100011&lng=en&nrm=iso&tlng=en