%0 Journal Article
%T Liver histology in co-infection of hepatitis C virus (HCV) and Hepatitis G virus (HGV)
%A STRAUSS
%A Edna
%A GAYOTTO
%A Luiz Carlos da Costa
%A FAY
%A Fabian
%A FAY
%A Oscar
%A FERNANDES
%A Helena Sabino
%A CHAMONE
%A Dalton de Alencar Fischer
%J Revista do Instituto de Medicina Tropical de S£¿o Paulo
%D 2002
%I Instituto de Medicina Tropical
%R 10.1590/S0036-46652002000200003
%X as little is known about liver histology in the co-infection of hepatitis c virus (hcv) and hepatitis g virus (hgv), hgv rna was investigated in 46 blood donors with hepatitis c, 22 of them with liver biopsy: co-infection hcv / hgv (n = 6) and hcv isolated infection (n = 16). besides staging and grading of inflammation at portal, peri-portal and lobular areas (brazilian consensus), the fibrosis progression index was also calculated. all patients had no symptoms or signs of liver disease and prevalence of hgv / hcv co-infection was 15.2%. most patients had mild liver disease and fibrosis progression index, calculated only in patients with known duration of infection, was 0.110 for co-infection and 0.130 for isolated hcv infection, characterizing these patients as "slow fibrosers". no statistical differences could be found between the groups, although a lesser degree of inflammation was always present in co-infection. in conclusion co-infection hcv / hgv does not induce a more aggressive liver disease, supporting the hypothesis that hgv is not pathogenic.
%K hepatitis c
%K hepatitis g
%K liver fibrosis
%K inflammatory activity.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0036-46652002000200003&lng=en&nrm=iso&tlng=en