%0 Journal Article
%T C cells in the thyroid of pinealectomized rats
%A Lima
%A Marcus Aurelho de
%A Lima
%A Lilian Margareth Biagioni de
%A Freitas
%A Leandro Lu¨ªs Lopes
%A Barbosa
%A Patr¨ªcia Fernanda Toledo
%A Borges
%A Maria de F¨¢tima
%A Reis
%A Luiz
%A Pereira
%A Gilberto de Araujo
%J Revista do Hospital das Cl¨ªnicas
%D 2003
%I Scientific Electronic Library Online
%R 10.1590/S0041-87812003000100005
%X purpose: to study quantitatively c cells in the thyroids of non-isogenic rats to determine the possible effects of pinealectomy on the number of these cells, and consequently on the synthesis and secretion of calcitonin. methods: twenty male rats of an outbred strain (200-300 g) were used in the present study. one group of 10 animals was pinealectomized 50 days prior to sacrifice. thyroid tissue was stained for calcitonin (dako corporation) at a 1:1500 dilution. the number of c cells observed was expressed as number of cells/cm2. data were analyzed statistically by mann-whitney test. results: the number of c cells in pinealectomized and normal animals ranged from 489 to 2084 per cm2 and 227 to 1584 per cm2, respectively, a difference that was statistically significant (p <0.05). conclusions: these results showed consistent differences in the number of c cells after pinealectomy when compared to controls. we believe that pinealectomy increases the number of c cells in the rat thyroid.
%K thyroid
%K c cells
%K pineal gland
%K rat
%K calcitonin.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0041-87812003000100005&lng=en&nrm=iso&tlng=en