%0 Journal Article
%T Dimorfismo sexual inmunitario: £¿pueden los esteroides sexuales polarizar el perfil de citocinas Th1/Th2?
%A De Le¨®n-Nava
%A Marco A
%A Morales-Montor
%A Jorge
%J Revista de investigaci¨®n cl¨ªnica
%D 2006
%I Scientific Electronic Library Online
%X cytokine secretion is a crucial aspect in immune system modulation. the secretion pattern of these molecules determines the immune response type that will confront a particular antigen, and this pattern can be at least of two types. a thl pattern, effective to eliminate mainly intracellular pathogens and a th2 pattern, crucial to eradicate extra cellular pathogens. there are many immunological factors that affect expression of these proteins and auto regulate the th1/th2 balance, but there are few evidences about effect of other protagonists of mammals physiology. this review focuses on the regulation of the th1/th2 cytokine secretion pattern of immune cells by sexual steroids. the evidences indicate that cytokines and steroids form a common chemical language effective to keep the balance between immune and endocrine systems. alterations of this delicate network can explain different pathologies where gender-associated differences exist and where sexual steroids are crucial factors.
%K sex steroids
%K polarization
%K immune response
%K cytokines
%K th1
%K th2.
%U http://www.scielo.org.mx/scielo.php?script=sci_abstract&pid=S0034-83762006000200009&lng=en&nrm=iso&tlng=en