%0 Journal Article
%T Drug treatment of hypertension: compliance and adverse reactions in a cohort of hypertensive patients in a primary care setting
%A Mino-Le¨®n
%A Dolores
%A Reyes-Morales
%A Hortensia
%A Galv¨¢n-Plata
%A Mar¨ªa Eugenia
%A Ponce-Monter
%A H¨¦ctor
%A Palma-Aguirre
%A Jos¨¦ Antonio
%A Amato
%A Dante
%A Figueras
%A Albert
%J Revista de investigaci¨®n cl¨ªnica
%D 2007
%I Scientific Electronic Library Online
%X objectives. the primary was to assess the frequency of therapeutic non-compliance due to adrs in a cohort of patients with recently diagnosed systemic hypertension. the secondary objectives were to evaluate the blood pressure control during the follow-up in the whole cohort and in patients who received non-steroidal anti-inflammatory drugs (nsaids). methods. a cohort of 73 recently diagnosed ambulatory hypertensive patients was followed-up for 6 months. validated questionnaires for identification of therapeutic scheme changes and adrs were applied monthly, during each medical visit. results. family physicians selected monotherapy in 79% of patients. the frequency of therapeutic non-compliance was 44%; non-compliance secondary to adr was 7%. systolic and diastolic blood pressure at the beginning of the study were 140 ¡À 15/90 ¡À 15 mm hg for the whole cohort. at the end of the study the figures were 130 ¡À 11/85 ¡À 6 (p < 0.001). patients receiving non-steroidal anti-inflammatory drugs (nsaids) had higher blood pressure levels than the groups of patients not receiving such kind of drugs (134 ¡À 10 vs. 128 ¡À 8 mm hg, p = 0.025 and 88 ¡À 7 vs. 83 ¡À 5 mm hg, p = 0.05). conclusions. the drugs used in the present study as monotherapy are considered acceptable choices for hypertension treatment. the frequency of therapeutic non-compliance was within the limits reported in the literature and the frequency of therapeutic non-compliance secondary to adrs in this cohort was lower than that reported in the literature. higher blood pressure was found in the group of patients receiving nsaids.
%K antihypertensive drugs
%K pharmacovigilance
%K adverse drug reactions
%K compliance
%K drug utilization study.
%U http://www.scielo.org.mx/scielo.php?script=sci_abstract&pid=S0034-83762007000100002&lng=en&nrm=iso&tlng=en