%0 Journal Article
%T Low sensitivity of polymerase chain reaction for diagnosis of tuberculous meningitis in southeastern Brazil
%A Brienze
%A Vania Maria Sabadoto
%A Tonon
%A £¿ngela Pedroso
%A Pereira
%A Fabr¨ªcio Jos¨¦ Tarelho
%A Liso
%A Elisabete
%A Tognola
%A Waldir Ant£¿nio
%A Santos
%A Manoel Armando Azevedo dos
%A Ferreira
%A Marcelo Urbano
%J Revista da Sociedade Brasileira de Medicina Tropical
%D 2001
%I Sociedade Brasileira de Medicina Tropical - SBMT
%R 10.1590/S0037-86822001000400015
%X two polymerase chain reaction (pcr) protocols showed low sensitivity (36% and 53% for tb amplicor and mpb64 nested pcr, respectively), when compared with classic microbiological methods (73% and 54% for ziehl-neelsen staining and culture, respectively), in the diagnosis of tuberculous meningitis in 91 patients in southeastern brazil. only three pcr-positive, microbiologically negative patients were found. analysis of sequential cerebrospinal fluid samples by nested pcr detected mycobacterium tuberculosis dna up to 29 days after the introduction of antituberculosis chemotherapy.
%K diagnosis of tuberculous meningitis
%K pcr
%K mycobacterium tuberculosis.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0037-86822001000400015&lng=en&nrm=iso&tlng=en