%0 Journal Article
%T Rapid Pharmacokinetic and Biodistribution Studies Using Cholorotoxin-Conjugated Iron Oxide Nanoparticles: A Novel Non-Radioactive Method
%A Michelle Jeung-Eun Lee
%A Omid Veiseh
%A Narayan Bhattarai
%A Conroy Sun
%A Stacey J. Hansen
%A Sally Ditzler
%A Sue Knoblaugh
%A Donghoon Lee
%A Richard Ellenbogen
%A Miqin Zhang
%A James M. Olson
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0009536
%X Recent advances in nanotechnology have led to the development of biocompatible nanoparticles for in vivo molecular imaging and targeted therapy. Many nanoparticles have undesirable tissue distribution or unacceptably low serum half-lives. Pharmacokinetic (PK) and biodistribution studies can help inform decisions determining particle size, coatings, or other features early in nanoparticle development. Unfortunately, these studies are rarely done in a timely fashion because many nanotechnology labs lack the resources and expertise to synthesize radioactive nanoparticles and evaluate them in mice.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0009536