%0 Journal Article
%T Immunophenotyping of circulating T cells in a mucosal leishmaniasis patient coinfected with HIV
%A Castellano
%A L¨²cio Roberto
%A Llaguno
%A Mauricio
%A Silva
%A Marcos Vin¨ªcius
%A Machado
%A Juliana Reis
%A Correia
%A Dalmo
%A Silva-Vergara
%A Mario Le¨®n
%A Rodrigues
%A Virmondes
%J Revista da Sociedade Brasileira de Medicina Tropical
%D 2011
%I Sociedade Brasileira de Medicina Tropical - SBMT
%R 10.1590/S0037-86822011000400025
%X hiv coinfection modifies the clinical course of leishmaniasis by promoting a th2 pattern of cytokine production. however, little information is available regarding the lymphocytic response in untreated coinfected patients. this work presents the immunophenotyping of leishmania-stimulated t cells from a treatment-na£¿ve hiv+ patient with ml. leishmania braziliensis antigens induced cd69 expression on cd3+cd4+ and cd3+cd8+ cells. it also increased il-4 intracellular staining on cd3+cd4+gata3- population and decreased the percentage of cd3+cd4+il-17+ cells. this suggests that modulations in the il-4r/stat6 pathway and the th17 population may serve as parasitic evasion mechanisms in hiv/ml. further studies are required to confirm these results.
%K mucosal leishmaniasis
%K leishmania braziliensis
%K hiv coinfection.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0037-86822011000400025&lng=en&nrm=iso&tlng=en