%0 Journal Article %T Immunophenotyping of circulating T cells in a mucosal leishmaniasis patient coinfected with HIV %A Castellano %A L¨²cio Roberto %A Llaguno %A Mauricio %A Silva %A Marcos Vin¨ªcius %A Machado %A Juliana Reis %A Correia %A Dalmo %A Silva-Vergara %A Mario Le¨®n %A Rodrigues %A Virmondes %J Revista da Sociedade Brasileira de Medicina Tropical %D 2011 %I Sociedade Brasileira de Medicina Tropical - SBMT %R 10.1590/S0037-86822011000400025 %X hiv coinfection modifies the clinical course of leishmaniasis by promoting a th2 pattern of cytokine production. however, little information is available regarding the lymphocytic response in untreated coinfected patients. this work presents the immunophenotyping of leishmania-stimulated t cells from a treatment-na£¿ve hiv+ patient with ml. leishmania braziliensis antigens induced cd69 expression on cd3+cd4+ and cd3+cd8+ cells. it also increased il-4 intracellular staining on cd3+cd4+gata3- population and decreased the percentage of cd3+cd4+il-17+ cells. this suggests that modulations in the il-4r/stat6 pathway and the th17 population may serve as parasitic evasion mechanisms in hiv/ml. further studies are required to confirm these results. %K mucosal leishmaniasis %K leishmania braziliensis %K hiv coinfection. %U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0037-86822011000400025&lng=en&nrm=iso&tlng=en