%0 Journal Article
%T Lessons from the epidemiological surveillance program, during the influenza A (H1N1) virus epidemic, in a reference university hospital of Southeastern Brazil
%A Moretti
%A Maria Luiza
%A Sinkoc
%A Ver£¿nica
%A Cardoso
%A Luis Gustavo de Oliveira
%A Camargo
%A Gema Jesus de
%A Bachur
%A Luis Felipe
%A Hofling
%A Christian Cruz
%A Angerami
%A Rodrigo
%A Trabasso
%A Pl¨ªnio
%A Garcia
%A M¨¢rcia Teixeira
%A Resende
%A Mariangela Ribeiro
%J Revista da Sociedade Brasileira de Medicina Tropical
%D 2011
%I Sociedade Brasileira de Medicina Tropical - SBMT
%R 10.1590/S0037-86822011005000048
%X introduction: the case definition of influenza-like illness (ili) is a powerful epidemiological tool during influenza epidemics. methods: a prospective cohort study was conducted to evaluate the impact of two definitions used as epidemiological tools, in adults and children, during the influenza a h1n1 epidemic. patients were included if they had upper respiratory samples tested for influenza by real-time reverse transcriptase polymerase chain reaction during two periods, using the ili definition (coughing + temperature > 38oc) in period 1, and the definition of severe acute respiratory infection (ars) (coughing + temperature > 38oc and dyspnoea) in period 2. results: the study included 366 adults and 147 children, covering 243 cases of ili and 270 cases of ars. laboratory confirmed cases of influenza were higher in adults (50%) than in children (21.6%) ( p < 0.0001) and influenza infection was more prevalent in the ili definition (53%) than ars (24.4%) (p < 0.0001). adults reported more chills and myalgia than children (p = 0.0001). oseltamivir was administered in 58% and 46% of adults and children with influenza a h1n1, respectively. the influenza a h1n1 case fatality rate was 7% in adults and 8.3% in children. the mean time from onset of illness until antiviral administration was 4 days. conclusions: the modification of ili to ars definition resulted in less accuracy in influenza diagnosis and did not improve the appropriate time and use of antiviral medication.
%K seasonal influenza
%K influenza a h1n1
%K epidemiological surveillance
%K influenza-like illness
%K acute respiratory syndrome.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0037-86822011000400001&lng=en&nrm=iso&tlng=en